According to new research published by a laboratory at the Hackensack Meridian Center for Discovery and Innovation (CDI), exhaled-breath test can be developed for detection of lung diseases including lung cancer. Two papers have been published by CDI Associate Member Olivier Loudig and colleagues where they have successfully collected and profiled lung biomarkers from human breath. They also developed animal models to expand their analysis and identify key markers for detection of metastatic lung cancer. These two publications have found the scientific roadmap towards achieving the goal for exhaled-breath test relevance for human patients.
“This innovative technology developed by Olivier Loudig offers promise and hope to patients who all too often receive a diagnosis too late for effective intervention,” said David Perlin, Ph.D., the chief scientific officer and executive vice president of the CDI. “This is what the CDI is all about: inspire science innovation to address unmet medical needs.”
In their study, the team focused on the capture and identification of nanoparticles known as extracellular vesicles which are released into extracellular space including blood, serum and other biofluids. The team at CDI has developed research programs for biomarker discovery and early detection of lung cancer using liquid biopsies. The CDI team assessed five types of airway samples from 69 subjects and determined that exhaled Evs contain microRNA expression profiles consistent with those obtained from deeper lung samples. They analyzed microRNA content of exhaled EVs from exhaled breath condensates collected from 18 subjects including 12 healthy and 6 with Stage-IV lung cancer. Their analyses confirmed that exhaled Evs selectively purified from breath of these subjects purified from breath of these subjects identified unique microRNA expression profiles to ascertain lung cancer patients.
“We envision that expanding our approach to study human primary and other secondary lung cancers, in adequately-powered animal studies, has the potential to identify relevant exhaled human EV biomarkers,” they wrote.
The information shared in this blog is for educational purposes only.
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