Lung cancer remains the leading cause behind cancer-related deaths worldwide. Researchers continue to search for new approaches to prevent or slow down this deadly disease. One such area is how metabolism influences cancer. Some molecules also affect the system of chemical modifications responsible for controlling how genes are expressed.
UCLA Study Examines Ca-αKG and Lung Cancer Growth
A new study led by researchers at UCLA Jonsson Comprehensive Cancer Center has found a dietary form of naturally occurring molecule may influence lung cancer growth differently in females and men. The findings have been published in the Journal Cell Reports and it suggested that Ca-αKG may influence lung cancer via epigenetic changes, chemical modifications that help controlling genes rather than by changing cancer cells’ basic energy metabolism.
Ca-αKG Reduced Lung Tumor Growth in Female Mice
In this study, they found that molecule called calcium alpha-ketoglitarate or Ca-αKG was able to reduce lung tumor growth in female mice. It was also able to activate genes associated with better outcomes in women having lung cancer.
Male and Female Mice Showed Opposite Responses
The team found that female mic receiving Ca-αKG had significantly smaller tumors and lower levels of tumor-cell proliferation in comparison with mice receiving control diet. On the other hand, male mice receiving Ca-αKG developed larger tumors and had higher levels of tumor-cell proliferation. But, the researchers do not know the reason why Ca-αKG increased tumor growth in male mice.
Study Highlights Role of Sex and Tumor Genetics
“These findings offer a glimpse into the complicated relationship among metabolism, cancer and biological sex,” said Dr. Claudio Scafoglio, associate professor of pulmonary and critical care medicine at UCLA and senior author of the study. “The fact that we observed opposite responses in male and female mice underscores the importance of understanding how sex and tumor genetics shape the response to these types of interventions”, he added.
Further Research Needed on Ca-αKG and Lung Cancer
Further studies are required to be carried out to determine why the response differs by sex and tumor genotype. These findings could help in forming better strategies for lung cancer prevention.
The information shared in this blog is for educational purposes only. You should always seek medical advice for any needs.
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FAQ
What is Ca-αKG?
Ca-αKG is calcium alpha-ketoglutarate, a dietary form of a naturally occurring molecule studied for its potential effects on cancer biology.
Did Ca-αKG reduce lung tumor growth?
In the UCLA study, Ca-αKG reduced lung tumor growth in female mice but was linked to increased tumor growth in male mice.
Why did Ca-αKG affect male and female mice differently?
Researchers do not yet know why the response differed. Sex and tumor genetics may influence how tumors respond.
Can Ca-αKG prevent lung cancer in humans?
The findings come from mouse research and do not establish that Ca-αKG prevents or treats lung cancer in humans.
What does the study reveal about lung cancer research?
The findings highlight the importance of studying metabolism, biological sex and tumor genetics when investigating potential lung cancer prevention strategies.