Small cell lung cancer is the deadliest forms of lung cancer with less than 7% of patients surviving five years after lung cancer diagnosis. Immunotherapy has benefited many lung cancer patients but with this type of cancer, it has shown limited results. Small cell lung cancer evades conventional immune cells and allows cancer cells to keep growing. It often gets detected at a later stage where it has already been spread beyond lungs.
Researchers Identify Immune Cells That Target Small Cell Lung Cancer
Researchers have identified specialized immune cells that can recognize and destroy small cell lung cancer. The discovery was made by researchers at the Walter and Eliza Hall Institute of Medical Research (WEHI) in Australia. The findings are published in the journal Cancer Cell. They suggest that specialized immune cells known as gamma delta T cells could pave a way to fight tumor.
Laboratory Models Show Cancer-Killing Potential
In this study, the team has developed miniature tumors in laboratory using tissue samples to investigate cancer-fighting abilities of the cells. They introduced gamma delta T cells into these models and found that the immune cells could identify and destroy cancer cells.
Tarlatamab and Zoledronate May Strengthen Immune Response
The team found those patients whose tumors contained great number of these cells. The team tested tarlatamab and zoledronate to find whether they could strengthen the immune response. In the laboratory experiments, the medicines substantially increased cells’ ability to kill cancer cells.
Researchers Explore New Immunotherapy Possibilities
Professor Kate Sutherland, the study’s senior author, said, “For decades, we’ve known that small cell lung cancer is exceptionally good at hiding from the immune system.” “We’ve found an immune cell that appears to be able to see through that disguise,” she added.
These findings could support the development of lung cancer treatment. Also, further research is required to find whether the approach is safe and effective in small cell lung cancer patients.
The information shared in this blog is for educational purposes only. You should always consult with your healthcare professional for any medical issues.
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