Lung Cancer is the most common forms of cancers among both men and women in the United States and worldwide. American Cancer Society estimates that there will be around 229,410 new diagnoses in the year 2026 alone. Also, about one in five of all cancer deaths is due to lung cancer.
Inherited Genetic Factors May Increase Lung Cancer Risk
In addition to the primary risk factors behind lung cancer of smoking and environmental exposures, a new study shows that in some people, inherited genetics also play a very useful role. Inherited genetic factors are known to increase the risk of developing lung cancer but are poorly understood. According to the researchers, EGFR T790M was first discovered in the year 2005 in a European family with multiple cases of lung cancer.
EGFR T790M Mutation Linked to Lung Cancer in Non-Smokers
Scientists have identified an inherited genetic mutation that is responsible for greatly increasing the risk of lung cancer, even among those who have never smoked. This mutation involves EGFR gene that helps in controlling growth, division and survival of cells. This new study has been published in Science. It looked at the EGFR T790M mutation by analysing genetic and health data from over 3 million people.
EGFR T790M Carriers May Face Higher Lung Cancer Risk
According to this new study, the carriers of the rare EGFR T790M mutation may have 62 times the risk of developing lung cancer than those who had never smoked. A single inherited mutation was responsible for a very large increase in lung cancer risk. The team was able to track the history of mutation and found that it may have come to the United States through the Southern Appalachian region around 200 years ago.
Genetic Testing and Lung Cancer Screening
By linking EGFR T790M to an increased lung cancer risk, it may help identify patients that could benefit from genetic testing and lung canver screening.
The information shared in this blog is for educational purposes only. You should always consult with your healthcare professional for any medical needs.
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FAQ
Can non-smokers develop lung cancer?
Yes. Lung cancer can occur in people who have never smoked, with genetics and other risk factors potentially playing a role.
What is the EGFR T790M mutation?
EGFR T790M is a genetic mutation that can occur as an inherited variant and has been linked to increased lung cancer risk.
Does EGFR T790M increase lung cancer risk?
The study reported a substantially higher lung cancer risk among carriers of the rare inherited EGFR T790M mutation.
Can genetic testing identify lung cancer risk?
Genetic testing can identify certain inherited variants associated with cancer risk, but testing decisions should be discussed with a qualified healthcare professional.
Should non-smokers get lung cancer screening?
Routine screening recommendations generally depend on individual risk factors. People with significant inherited risk should discuss appropriate screening with their healthcare professional.