Lung Cancer is one of the leading causes of cancer-related deaths worldwide and early detection remains crucial for improving the survival rates. The researchers at Michigan State University (MSU) have found that honeybees can detect biomarkers in human breath linked to lung cancer. The research has been published in Biosensors and Bioelectronics. It could pave the way for highly sensitive cancer diagnostics inspired by nature.
The Experiment
In this research, they also found that the insects can differentiate between different types of lung cancer as well. They utilize their powerful sense of smell to find it. Honeybees are always known for their extraordinary sense of smell. They are able to detect flowers, pheromones and even chemical changes in their hive as well.
In this experiment, Elissa Cox, a former MSU lab manager, and Michael Parnas, created a synthetic mixture that mimicked breath of lung cancer patients. This mixture contained specific compounds like trichloroethylene and 2-methylheptance and these are reliable chemical biomarkers for early detection. Another mixture was also created by them to represent healthy breath.
The researchers exposed about 20 honeybees to synthetic breath samples to check if they could accurately distinguish cancer-related scents. Cox designed a custom 3D-printed harness that held the bees in place while tiny electrodes monitored their brains. When the odours passed over the bees’ antennae, the electrodes recorded distinct neural firing patterns. The honeybees showed measurable changes in brain activity when they encountered cancer-associated compounds. They also detected chemicals at concentrations as low as parts per billion.
Bees vs. Dogs in Lung Cancer Detection
The research also tested whether honeybees could differentiate between lung cancer cell lines. While dogs have often been used for smell-based disease detection, honeybees offer unique advantages. They are smaller, easier to study under controlled lab conditions, and researchers can record their neural activity directly with electrode-based sensors.
Conclusion
The MSU study highlights a fascinating approach to disease detection. With further research, honeybees may contribute to developing highly sensitive and cost-effective methods for early lung cancer diagnosis; potentially saving countless lives.
The information shared in this blog is for educational purposes only. You should always consult with your healthcare provider for any medical needs.
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